A phase II study of radioimmunotherapy with intraventricular ¹³¹ I-3F8 for medulloblastoma.

ABSTRACT:

Background

High-risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell-surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular ¹³¹ I-labeled 3F8 in patients with MB on a phase II clinical trial.

Methods

Patients with histopathologically confirmed high-risk or recurrent MB were eligible for cRIT. After determining adequate cerebrospinal fluid (CSF) flow, patients received 2 mCi (where Ci is Curie) ¹²⁴ I-3F8 or ¹³¹ I-3F8 with nuclear imaging for dosimetry, followed by up to four therapeutic (10 mCi/dose) ¹³¹ I-3F8 injections. Dosimetry estimates were based on ser

SUBMITTER: Kramer K 

PROVIDER: S-EPMC6692907 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature