DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.

ABSTRACT:

Background

Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atypical choroid plexus papilloma (aCPP); however, these distinctions can be challenging. Standard treatment of CPC is very aggressive and often leads to severe damage to the young child's brain. Therefore, it is crucial to distinguish between CPC and less aggressive entities (CPP or aCPP) to avoid unnecessary exposure of the young patient to neurotoxic therapy. To better stratify CPTs, we utilized DNA methylation (DNAm) to identify prognostic epigenetic biomarkers for CPCs.

Methods

We obtained DNA methylation profiles of 34 CPTs using the HumanMethylation450 Bea

SUBMITTER: Pienkowska M 

PROVIDER: S-EPMC6692938 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature