Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials.

ABSTRACT: Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, a congenital neurodevelopmental disorder. Loss-of-function mutations of PHF6 are detected in patients with acute leukemia, mainly of T-cell lineage and in a small proportion of myeloid lineage. The functions of PHF6 in physiological hematopoiesis and leukemogenesis remain incompletely defined. To address this question, we generated a conditional Phf6 knockout mouse model and investigated the impact of Phf6 loss on the hematopoietic system. We found that Phf6 knockout mice at 8 weeks of age had reduced numbers of CD4⁺ and CD8⁺ T cell

SUBMITTER: Hsu YC 

PROVIDER: S-EPMC6693005 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature