Nix-mediated mitophagy regulates platelet activation and life span.

ABSTRACT: Platelet activation requires fully functional mitochondria, which provide a vital energy source and control the life span of platelets. Previous reports have shown that both general autophagy and selective mitophagy are critical for platelet function. However, the underlying mechanisms remain incompletely understood. Here, we show that Nix, a previously characterized mitophagy receptor that plays a role in red blood cell maturation, also mediates mitophagy in platelets. Genetic ablation of Nix impairs mitochondrial quality, platelet activation, and FeCl₃-induced carotid arterial thrombosis without affecting the expression of platelet glycoproteins (GPs) such as GPIb, GPVI, and α_IIbβ₃ Metabolic analysis revealed decreased mitochondrial membrane potent

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6693007 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature