Kinetics of immune cell reconstitution predict survival in allogeneic bone marrow and G-CSF-mobilized stem cell transplantation.

ABSTRACT: The clinical utility of monitoring immune reconstitution after allotransplant was evaluated using data from Blood and Marrow Transplant Clinical Trials Network BMT CTN 0201 (NCT00075816), a multicenter randomized study of unrelated donor bone marrow (BM) vs granulocyte colony-stimulating factor (G-CSF)-mobilized blood stem cell (G-PB) grafts. Among 410 patients with posttransplant flow cytometry measurements of immune cell subsets, recipients of G-PB grafts had faster T-cell reconstitution than BM recipients, including more naive CD4⁺ T cells and T-cell receptor excision circle-positive CD4⁺ and CD8⁺ T cells at 3 months, consistent with better thymic function. Faster reconstitution of CD4⁺ T cells and naive CD4⁺ T cells at 1 month and

SUBMITTER: Waller EK 

PROVIDER: S-EPMC6693008 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature