Kinetics of MSC-based enzyme therapy for immunoregulation.

ABSTRACT:

Background

Mesenchymal stromal cells (MSC) demonstrate innate and regulatory immunologic functions and have been widely explored for cell therapy applications. Mechanisms by which MSCs achieve therapeutic effects are theorized, though appropriate dosing and duration of these mechanisms in vivo warrant deeper investigation. One, rapid immunosuppressive function of MSCs is through ectoenzyme expression of CD73 and CD39 which cooperatively hydrolyze inflammatory, extracellular adenosine triphosphate (ATP) to anti-inflammatory adenosine. Extracellular ATP has a key role in autoimmune and inflammatory diseases, which administered MSCs have the potential to modulate in a timescale that is befitting of shorter acting therapeutic function.

Methods

In vitro experiments were performed

SUBMITTER: Burr A 

PROVIDER: S-EPMC6693124 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature