Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.

ABSTRACT:

Background

P. falciparum malaria has been recognized as one of the prominent evolutionary selective forces of human genome that led to the emergence of multiple host protective alleles. A comprehensive understanding of the genetic bases of severe malaria susceptibility and resistance can potentially pave ways to the development of new therapeutics and vaccines. Genome-wide association studies (GWASs) have recently been implemented in malaria endemic areas and identified a number of novel association genetic variants. However, there are several open questions around heritability, epistatic interactions, genetic correlations and associated molecular pathways among others. Here, we assess the progress and pitfalls of severe malaria susceptibility GWASs and discuss the biology of the n

SUBMITTER: Damena D 

PROVIDER: S-EPMC6693204 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature