Integrin αvβ3-Targeted [⁶⁴Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy.

ABSTRACT: Copper sulfide (CuS) nanoparticles have been considered one of the most clinical relevant nanosystems because of their straightforward chemistry, small particle size, low toxicity, and intrinsic theranostic characteristics. In our previous studies, radioactive [⁶⁴Cu]CuS nanoparticles were successfully developed to be used as efficient radiotracers for positron emission tomography and for photothermal ablation therapy of cancer cells using near-infrared laser irradiation. However, the major challenge of CuS nanoparticles as a theranostic platform is the lack of a means for effective targeted delivery to the tumor site. To overcome this challenge, we designed and synthesized angiogenesis-targeting [⁶⁴Cu]CuS nanoparticles, which are coupled with cyclic RGDfK peptide [c(R

SUBMITTER: Cui L 

PROVIDER: S-EPMC6693325 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature