Cross-Species Gene Expression Analysis Reveals Gene Modules Implicated in Human Osteosarcoma.

ABSTRACT: Background: Osteosarcoma (OS) is one of the malignant bone tumors occurring in both human and canine, and in both of them, it is characterized by a high rate of metastasis and poor prognosis. Cross-species analysis reveals previously neglected molecular or signaling pathways involved in the progression of diseases, and dogs are genetically comparable to humans and live in similar environments. Therefore, the aim of this study was to find out OS hub genes through a cross-species analysis. Materials and Methods: All the human and canine OS gene expression data obtained by the Affymetrix platform were collected. After quality assessment and normalization, co-expression network was performed using weighted gene co-expression network analysis (WGCNA). Species-specific modules and

SUBMITTER: Jin Z 

PROVIDER: S-EPMC6693360 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature