Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

ABSTRACT:

Background

Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium.

Objectives

The aim of this study was to test the hypothesis that magnesium supplementation differentially affects vitamin D metabolism dependent on baseline 25-hydroxyvitamin D [25(OH)D] concentration.

Methods

The study included 180 participants aged 40-85 y and is a National Cancer Institute independently funded ancillary study, nested within the Personalized Prevention of Colorectal C

SUBMITTER: Dai Q 

PROVIDER: S-EPMC6693398 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature