Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs.

ABSTRACT: The asymmetric cycloaddition of TIPS nitronate catalyzed by "Cu(II)-bisoxazoline" gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β-hydroxy ketone.

SUBMITTER: Feng J 

PROVIDER: S-EPMC6693402 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature