Installation of -SO₂F groups onto primary amides.

ABSTRACT: A protocol of SO₂F₂-mediated installation of sulfonyl fluoride onto primary amides has been developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO₂F moieties for application in the discovery of new therapeutics.

SUBMITTER: Liu J 

PROVIDER: S-EPMC6693406 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature