A Comprehensive Map of Genetic Variation in the World's Largest Ethnic Group-Han Chinese.

ABSTRACT: As are most non-European populations, the Han Chinese are relatively understudied in population and medical genetics studies. From low-coverage whole-genome sequencing of 11,670 Han Chinese women we present a catalog of 25,057,223 variants, including 548,401 novel variants that are seen at least 10 times in our data set. Individuals from this data set came from 24 out of 33 administrative divisions across China (including 19 provinces, 4 municipalities, and 1 autonomous region), thus allowing us to study population structure, genetic ancestry, and local adaptation in Han Chinese. We identified previously unrecognized population structure along the East-West axis of China, demonstrated a general pattern of isolation-by-distance among Han Chinese, and reported unique regional signals of admi

SUBMITTER: Chiang CWK 

PROVIDER: S-EPMC6693441 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature