Unveiling the dynamic interplay between the hub- and spoke-components of the brain's semantic system and its impact on human behaviour.

ABSTRACT: The neural architecture of semantic knowledge comprises two key structures: (i) A set of widely dispersed regions, located adjacent to the sensorimotor cortices, serve as spokes that represent various modality-specific and context-dependent contents. (ii) The anterior-temporal lobe (ATL) serves as a hub that computes the nonlinear mappings required to transform modality-specific information into pan-modality, multifaceted concepts. Little is understood regarding whether neural dynamics between the hub and spokes might flexibly alter depending on the nature of a concept and how it impinges upon behaviour. Using fMRI, we demonstrate for the first time that the ATL serves as a 'pivot' which dynamically forms flexible long-range networks with cortical modules specialised for different domains

SUBMITTER: Chiou R 

PROVIDER: S-EPMC6693526 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature