Breast milk IgA to foods has different epitope specificity than serum IgA-Evidence for entero-mammary link for food-specific IgA?

ABSTRACT:

Background

We have previously shown that maternal cow's milk (CM) elimination results in downregulation of CM-specific IgA antibody levels in BM, but not in serum, suggesting that an entero-mammary link may exist for food-specific antibody-secreting cells.

Objective

We sought to investigate whether food-specific IgA epitope profiles differ intra-individually between mother's serum and BM. We also examined how infants' food epitope-specific IgA develops in early infancy and the relationship of IgA epitope recognition with development of cow's milk allergy (CMA).

Methods

We measured specific IgA to a series of overlapping peptides in major CM allergens (α_s1 -, α_s2 -, β- and κ-caseins and β-lactoglobulin) in paired maternal and infant serum as well

SUBMITTER: Seppo AE 

PROVIDER: S-EPMC6693637 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature