Mortality After Cryptococcal Infection in the Modern Antiretroviral Therapy Era.

ABSTRACT:

Background

The prevalence of cryptococcosis in people living with HIV (PLWH) in the developed world has decreased considerably in the modern antiretroviral therapy (ART) era. Although early mortality of PLWH with opportunistic infections is well understood, overall mortality has not been previously evaluated.

Methods

We conducted a retrospective cohort study of cryptococcosis in PLWH from January 1, 2002, to July 1, 2017. Data were also evaluated before and after 2008 to evaluate the possible effect of modern ART on outcomes. Death date was obtained from the hospital's medical informatics database and the Social Security Death Index. Participants were grouped as survivors, early-mortality (death <90 days), and late-mortality (death ≥90 days) individuals.

Results

We re

SUBMITTER: Hevey MA 

PROVIDER: S-EPMC6693647 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature