Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines.

ABSTRACT: A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

SUBMITTER: Vanable EP 

PROVIDER: S-EPMC6693864 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature