Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing.

ABSTRACT:

Purpose

Drug development is becoming increasingly expensive and time consuming. Drug repurposing is one potential solution to accelerate drug discovery. However, limited research exists on the use of electronic health record (EHR) data for drug repurposing, and most published studies have been conducted in a hypothesis-driven manner that requires a predefined hypothesis about drugs and new indications. Whether EHRs can be used to detect drug repurposing signals is not clear. We want to demonstrate the feasibility of mining large, longitudinal EHRs for drug repurposing by detecting candidate noncancer drugs that can potentially be used for the treatment of cancer.

Patients and methods

By linking cancer registry data to EHRs, we identified 43,310 patients with cancer treated a

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6693869 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature