Dataset Information

Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits.

ABSTRACT: Computational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized models from different brain regions and species. Model structure and parameters can be automatically visualized and their dynamical properties explored through browser-based simulations. Infrastructure and tools for collaborative interaction, development, and testing are also provided. We demonstrate how existing components can be reused by constructing new models of inhibition-stabilized cortical networks that match recent experimental results. These features of Open Source Brain improve the accessibility, transparency, and reproducibility of models and facilitate their reuse by the wider community.

SUBMITTER: Gleeson P

PROVIDER: S-EPMC6693896 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits.

Gleeson Padraig P Cantarelli Matteo M Marin Boris B Quintana Adrian A Earnshaw Matt M Sadeh Sadra S Piasini Eugenio E Birgiolas Justas J Cannon Robert C RC Cayco-Gajic N Alex NA Crook Sharon S Davison Andrew P AP Dura-Bernal Salvador S Ecker András A Hines Michael L ML Idili Giovanni G Lanore Frederic F Larson Stephen D SD Lytton William W WW Majumdar Amitava A McDougal Robert A RA Sivagnanam Subhashini S Solinas Sergio S Stanislovas Rokas R van Albada Sacha J SJ van Geit Werner W Silver R Angus RA

Neuron 20190611 3

Computational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized mode ...[more]

PMID: 31201122

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Dataset Information

Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits.

Publications

Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits.

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