Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation.

ABSTRACT: Malignant brain neoplasms have a poor prognosis despite aggressive treatments. Animal models and evidence from human bodily tumors reveal that sustained reduction in tumor perfusion via electrical stimulation promotes tumor necrosis, therefore possibly representing a therapeutic option for patients with brain tumors. Here, we demonstrate that transcranial electrical stimulation (tES) allows to safely and noninvasively reduce intratumoral perfusion in humans. Selected patients with glioblastoma or metastasis underwent tES, while perfusion was assessed using magnetic resonance imaging. Multichannel tES was applied according to personalized biophysical modeling, to maximize the induced electrical field over the solid tumor mass. All patients completed the study and tolerated the procedure wit

SUBMITTER: Sprugnoli G 

PROVIDER: S-EPMC6693907 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature