Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia.

ABSTRACT: Pneumonia poses profound health threats to preterm infants. Alveolar macrophages (AMs) eliminate inhaled pathogens while maintaining surfactant homeostasis. As AM development only occurs perinatally, therapies that accelerate AM maturation in preterms may improve outcomes. We tested therapeutic rescue of AM development in mice lacking the actin-bundling protein L-plastin (LPL), which exhibit impaired AM development and increased susceptibility to pneumococcal lung infection. Airway administration of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) to LPL^-/- neonates augmented AM production. Airway administration distinguishes the delivery route from prior human infant trials. Adult LPL^-/- animals that received neonatal GM-CSF were protected from e

SUBMITTER: Todd EM 

PROVIDER: S-EPMC6693910 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature