The right treatment for the right ventricle.

ABSTRACT:

Purpose of review

Right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH). Although substantial progress has been made in understanding the development of RV failure in the last decennia, this has not yet resulted in the development of RV selective therapies. In this review, we will discuss the current status on the treatment of RV failure and potential novel therapeutic strategies that are currently being investigated in clinical trials.

Recent findings

Increased afterload results in elevated wall tension. Consequences of increased wall tension include autonomic disbalance, metabolic shift and inflammation, negatively affecting RV contractility. Compromised RV systolic function and low car

SUBMITTER: Groeneveldt JA 

PROVIDER: S-EPMC6693931 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature