Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma.

ABSTRACT: Copper (Cu) is a tightly regulated micronutrient that functions as a structural or catalytic cofactor for specific proteins essential for a diverse array of biological processes. While the study of the extremely rare genetic diseases, Menkes and Wilson, has highlighted the requirement for proper Cu acquisition and elimination in biological systems for cellular growth and proliferation, the importance of dedicated Cu transport systems, like the Cu chaperones ATOX1 and CCS, in the pathophysiology of cancer is not well defined. We found that ATOX1 was significantly overexpressed in human blood, breast, and skin cancer samples, while CCS was significantly altered in human brain, liver, ovarian, and prostate cancer when compared to normal tissue. Further analysis of genetic expression data in C

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC6693990 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature