Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies.

ABSTRACT: Satellite cells (SCs) are the main muscle stem cells responsible for its regenerative capacity. In muscular dystrophies, however, a failure of the regenerative process results in muscle degeneration and weakness. To analyze the effect of different degrees of muscle degeneration in SCs behavior, we studied adult muscle of the dystrophic strains: DMD^mdx, Large^myd, DMD^mdx/Large^myd, with variable histopathological alterations. Similar results were observed in the dystrophic models, which maintained normal levels of PAX7 expression, retained the Pax7-positive SCs pool, and their proliferation capacity. Moreover, elevated expression of MYOG, an important myogenic factor, was also observed. The ability to form new fibers was verified by the presence of

SUBMITTER: Ribeiro AF 

PROVIDER: S-EPMC6694188 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature