Trivalent influenza vaccination randomized control trial of pregnant women and adverse fetal outcomes.

ABSTRACT:

Introduction

The purpose of this study was to evaluate the association of influenza vaccine during pregnancy and adverse fetal outcomes. Preventing fetal death, low birth weight, small for gestational age birth and preterm birth are important potential effects of antenatal maternal influenza immunization for which there are conflicting data.

Materials and methods

A double-blind, randomized, placebo-controlled clinical trial of trivalent inactivated influenza vaccine was conducted in South Africa from March 2011 until after the 2012 influenza season when the infants born had reached the age of 24 weeks. Mothers were administered the vaccine or placebo during pregnancy at a gestation of 20 to 36 weeks. A comparison of rates of fetal death, low birth weight, small for gestation

SUBMITTER: Simoes EAF 

PROVIDER: S-EPMC6694200 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature