High TRIAP1 expression in penile carcinoma is associated with high risk of recurrence and poor survival.

ABSTRACT:

Background

TP53-regulated inhibitor of apoptosis 1 (TRIAP1), also known as p53 cell survival factor or p53CSV, is reported to be associated with resistance of apoptosis in different human malignancies, but the potential role of TRIAP1 in penile carcinoma (PeCa) has not been well studied. This study aimed to analyze the association between TRIAP1 expression and clinical outcome in PeCa patients.

Methods

Bioinformatics was used to analyze the differential TRIAP1 expression in PeCa compared with normal tissues in Gene Expression Omnibus (GEO) Dataset (GSE57955). The expression of TRIAP1 in tumor specimens from 57 patients undergoing radical penile surgery was detected by immunohistochemistry (IHC). Differential TRIAP1 expression in various human malignancies was also assessed b

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6694233 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature