MiRMap: Profiling 14q32 microRNA Expression and DNA Methylation Throughout the Human Vasculature.

ABSTRACT: Aims: MicroRNAs are regulators of (patho)physiological functions with tissue-specific expression patterns. However, little is known about inter-vascular differences in microRNA expression between blood vessel types or vascular beds. Differences in microRNA expression could influence cardiovascular pathophysiology at specific sites in the vasculature. Therefore, we aimed to map expression profiles of vasoactive 14q32 microRNAs throughout the human vasculature, as well as expression of vasoactive target genes of the 14q32 microRNAs. Furthermore, we aimed to map the DNA methylation status of the 14q32 locus, which has been linked to cardiovascular disease. Methods and Results: We collected 109 samples from different blood vessels, dissected during general surgery. Expression of

SUBMITTER: Goossens EAC 

PROVIDER: S-EPMC6694280 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature