Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury.

ABSTRACT: The neuroinflammatory response to traumatic brain injury (TBI) is critical to both neurotoxicity and neuroprotection, and has been proposed as a potentially modifiable driver of secondary injury in animal and human studies. Attempts to broadly target immune activation have been unsuccessful in improving outcomes, in part because the precise cellular and molecular mechanisms driving injury and outcome at acute, subacute, and chronic time points after TBI remain poorly defined. Microglia play a critical role in neuroinflammation and their persistent activation may contribute to long-term functional deficits. Activated microglia are characterized by morphological transformation and transcriptomic changes associated with specific inflammatory states. We analyzed the temporal course of changes

SUBMITTER: Izzy S 

PROVIDER: S-EPMC6694299 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature