Dataset Information

Sleep as a Therapeutic Target in the Aging Brain.

ABSTRACT: Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.

SUBMITTER: Bah TM

PROVIDER: S-EPMC6694322 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Sleep as a Therapeutic Target in the Aging Brain.

Bah Thierno M TM Goodman James J Iliff Jeffrey J JJ

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20190701 3

Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally lin ...[more]

PMID: 31376067

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Dataset Information

Sleep as a Therapeutic Target in the Aging Brain.

Publications

Sleep as a Therapeutic Target in the Aging Brain.

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