Plasma-Based Strategies for Therapeutic Modulation of Brain Aging.

ABSTRACT: Age is the primary risk factor for the vast majority of disorders, including neurodegenerative diseases impacting brain function. Whether the consequences of aging at the biological level can be reversed, or age-related changes prevented, to change the trajectory of such disorders is thus of extreme interest and value. Studies using young plasma, the acellular component of blood, have demonstrated that aging is malleable, with the ability to restore functions in old animals. Fascinatingly, this functional improvement is even observed in the brain, despite the blood-brain barrier, indicating that peripheral sources can effectively impact central sites leading to clinically relevant changes such as enhancement of cognitive function. A plasma-based approach is also attractive as aging is inhe

SUBMITTER: Kheifets V 

PROVIDER: S-EPMC6694331 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature