Insulin Resistance Predicts Postoperative Cognitive Dysfunction in Elderly Gastrointestinal Patients.

ABSTRACT:

Background

Members of the aging population who undergo surgery are at risk of postoperative cognitive dysfunction (POCD). Exploring an effective and reliable early predictor of POCD is essential to the identification of high-risk patients and to making prospective decisions. The purpose of this study was to examine whether preoperative insulin resistance is an independent predictor of POCD.

Methods

A total of 124 patients aged 60 years and older and who were scheduled for gastrointestinal surgery were enrolled in a prospective observational clinical study. All participants completed a battery of neuropsychological tests before surgery and 7 days later. POCD was defined as a decline of at least 1.5 SD on two or more of neuropsychological tests. Plasma concentration of the tum

SUBMITTER: He X 

PROVIDER: S-EPMC6694405 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature