Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma.

ABSTRACT:

Background

Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases functionally contribute to tumor development and progression. Here, we searched for lncRNAs useful as biomarkers in HNSCC.

Methods

Public datasets were mined for lncRNA candidates. Two independent HNSCC tissue sets and a bladder cancer tissue set were analyzed by RT-qPCR. Effects of lncRNA overexpression or downregulation on cell proliferation, clonogenicity, migration and chemosensitivity were studied in HNSCC cell lines.

Results

Data mining revealed prominently CASC9, a lncRNA significantly overexpressed in HNSCC tumor tissues according to the TCGA

SUBMITTER: Sassenberg M 

PROVIDER: S-EPMC6694542 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature