G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.

ABSTRACT:

Background

Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of GPR64 has not been studied in endometrial cancer. Our objective is to investigate the role of GPR64 in endometrial cancer.

Methods

We examined the levels of GPR64 in human endometrioid endometrial carcinoma by immunohistochemistry analysis. To determine a tumor suppressor role of GPR64 in endometrial cancer, we used a siRNA loss of function approach in human endometrial adenocarcinoma cell lines.

Results

GPR64 levels were remarkably lower in 10 of 21 (47.62%) of endometrial carcinoma samples compared to control. Depletion of GPR64 by siRNA transfection

SUBMITTER: Ahn JI 

PROVIDER: S-EPMC6694613 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature