Modafinil in the rehabilitation of a patient with post-surgical posterior fossa syndrome: a lesson to be learned?

ABSTRACT: Disorders of the cerebellum may present with motor, cognitive, behavioral and affective symptoms. There is a growing interest in developing neuroanatomical models of symptoms generation that involve the cerebellum and the cerebello-cortical connections. We describe an exciting first case report of successful use of Modafinil in an adult patient with post-operative posterior fossa syndrome. Following resection of a melanoma metastasis in the cerebellum the patient developed striking affective and behavioral symptoms in the form of withdrawn flat mood and disengagement. This neurobehavioral presentation severely impacted on his quality of life, independence, and ability to engage in the neuro-rehabilitative program. Pharmacological treatment with Modafinil ameliorated these emotional and beh

SUBMITTER: Molinari E 

PROVIDER: S-EPMC6694614 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature