Enhancement of cartilage repair through the addition of growth plate chondrocytes in an immature skeleton animal model.

ABSTRACT:

Background

The treatment of articular cartilage damage is a major clinical problem. More often, this clinical issue affects children, which forces doctors to find the best treatment method.

Methods

The aim of this experimental study on 2-month-old Landrace pigs was to compare the results of two cartilage defect treatments: (1) filling the cartilage defect with a scaffold incubated with bone marrow aspirate supplemented with growth plate chondrocytes (the CELLS group) and (2) filling the cartilage defect with an empty scaffold implanted after drilling the subchondral bone (the CTRL group). The treatment outcomes were assessed macroscopically and microscopically.

Results

Based on the macroscopic evaluation, all animals showed a nearly normal morphology, with an average

SUBMITTER: Tomaszewski R 

PROVIDER: S-EPMC6694631 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature