Comprehensive molecular and clinical characterization of Asian melanoma patients treated with anti-PD-1 antibody.

ABSTRACT:

Background

Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with anti-PD-1 antibody.

Methods

Patients with recurrent or metastatic melanoma who began anti-PD-1 antibody therapy between January 2015 and April 2018 were retrospectively reviewed. Patients who underwent next-generation sequencing were also analyzed.

Results

A total of 152 patients were included. The median age was 61 years, and 53% of patients were female. A total of 56 patients (37%) received immunotherapy as second-line or greater chemotherapy. Primary sites were acral (38%), mucosal (31%), cutaneous (24%), uveal (2%), and unknown (5%). The overall r

SUBMITTER: Lee J 

PROVIDER: S-EPMC6694646 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature