In silico evidence of de novo interactions between ribosomal and Epstein - Barr virus proteins.

ABSTRACT:

Background

Association of Epstein-Barr virus (EBV) encoded latent gene products with host ribosomal proteins (RPs) has not been fully explored, despite their involvement in the aetiology of several human cancers. To gain an insight into their plausible interactions, we employed a computational approach that encompasses structural alignment, gene ontology analysis, pathway analysis, and molecular docking.

Results

In this study, the alignment analysis based on structural similarity allows the prediction of 48 potential interactions between 27 human RPs and the EBV proteins EBNA1, LMP1, LMP2A, and LMP2B. Gene ontology analysis of the putative protein-protein interactions (PPIs) reveals their probable involvement in RNA binding, ribosome biogenesis, metabolic and biosynthetic pr

SUBMITTER: Sim EU 

PROVIDER: S-EPMC6694676 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature