Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes.

ABSTRACT: Mendelian randomization (MR) estimates the causal effect of exposures on outcomes by exploiting genetic variation to address confounding and reverse causation. This method has a broad range of applications, including investigating risk factors and appraising potential targets for intervention. MR-Base has become established as a freely accessible, online platform, which combines a database of complete genome-wide association study results with an interface for performing Mendelian randomization and sensitivity analyses. This allows the user to explore millions of potentially causal associations. MR-Base is available as a web application or as an R package. The technical aspects of the tool have previously been documented in the literature. The present article is complementary to this as it

SUBMITTER: Walker VM 

PROVIDER: S-EPMC6694718 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature