Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer.

ABSTRACT: As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis. The identification of proteins that undergo calpain cleavage in a site-specific manner is the necessary foundation for understanding the exact molecular mechanisms and regulatory roles of calpain-mediated cleavage. In contrast with time-consuming and labor-intensive experimental methods, computational approaches for detecting calpain cleavage sites have attracted wide attention due to their efficiency and convenience. In this study, we established a novel computational tool named DeepCalpain (http://deepcalpain.cancerbio.info/) for predicting the potential calpain cleavage

SUBMITTER: Liu ZX 

PROVIDER: S-EPMC6694742 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature