Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in Caenorhabditis elegans.

ABSTRACT: Caffeine and related purine alkaloids are common ingredients of many stimulating drinks. Studies have shown that lower concentrations of caffeine have a protective role in aging-related disorders. However, the associated mode of action of caffeine and its related methylxanthines is still not clear. In this study, we demonstrated that caffeine and theophylline promote longevity in Caenorhabditis elegans. Lifespan studies with the wild type, DAF-16 and SKN-1 mutant strains indicated that the methylxanthines-mediated lifespan extension in C. elegans was independent of DAF-16/FOXO and SKN-1. All the tested methylxanthines could protect C. elegans against acute oxidative stress. At early stages of life, an increase of ROS (reactive oxygen species) induced the translocation

SUBMITTER: Li H 

PROVIDER: S-EPMC6694850 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature