Prediction of deleterious single nucleotide polymorphisms and their effect on the sequence and structure of the human CCND1 gene.

ABSTRACT:

Objective

The CCND1 gene expresses a protein, G1/S-specific cyclin, that regulates the G1/S transition in the cell cycle and also inhibits retinoblastoma (RB) proteins. Overexpression or rearrangements of this gene can result in various tumours. This study aimed to identify possible deleterious non-synonymous single nucleotide polymorphisms (SNP's) of CCND1 using computational methods.

Methods

SNPs in the human CCND1 gene were retrieved from dbSNP. These SNPs were screened by the Sorting Intolerant From Tolerant (SIFT) algorithm and the PredictSNP classification. Mutants with deleterious SNPs were built using Discovery Studio 3.5, and dynamics studies were performed on native and mutant varieties.

Results

In Homo sapiens, 1194 SNPs were fou

SUBMITTER: Yoganarasimha B 

PROVIDER: S-EPMC6695066 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature