DDT and Breast Cancer: Prospective Study of Induction Time and Susceptibility Windows.

ABSTRACT:

Background

In a previous Child Health and Development Studies report, p, p'-DDT was associated with a fivefold increased risk of premenopausal (before age 50 years) breast cancer for women first exposed before puberty. Here we extend our observation to breast cancer diagnosed during early postmenopause (ages 50-54 years) to determine whether age at diagnosis modifies the interaction of DDT with age at exposure.

Methods

We conducted a second prospective, nested case-control study in the Child Health and Development Studies (153 incident breast cancer cases diagnosed at ages 50-54 years and 432 controls matched to cases on birth year). These were analyzed separately and pooled with our previous study (129 breast cancer cases diagnosed at ages 31-49 years and 129 controls match

SUBMITTER: Cohn BA 

PROVIDER: S-EPMC6695310 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature