Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder.

ABSTRACT:

Rationale

Patients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior cingulate cortex as a key locus of dysfunction. Considerable evidence has linked prediction error processing to dopaminergic function.

Objective

In this study, we investigate potential dopaminergic dysfunction during reward processing in the context of OCD.

Methods

We studied OCD patients (n = 18) and controls (n = 18) whilst they learned probabilistic associations between abstract stimuli and monetary rewards in the fMRI scanner involving administration (on separate visits) of a dopamine receptor agonist, pramipexole 0.5 mg; a dopamine receptor ant

SUBMITTER: Murray GK 

PROVIDER: S-EPMC6695357 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature