Alternate subunit assembly diversifies the function of a bacterial toxin.

ABSTRACT: Bacterial toxins with an AB₅ architecture consist of an active (A) subunit inserted into a ring-like platform comprised of five delivery (B) subunits. Salmonella Typhi, the cause of typhoid fever, produces an unusual A₂B₅ toxin known as typhoid toxin. Here, we report that upon infection of human cells, S. Typhi produces two forms of typhoid toxin that have distinct delivery components but share common active subunits. The two typhoid toxins exhibit different trafficking properties, elicit different effects when administered to laboratory animals, and are expressed using different regulatory mechanisms and in response to distinct metabolic cues. Collectively, these results indicate that the evolution of two typhoid toxin variants has conferred functional ver

SUBMITTER: Fowler CC 

PROVIDER: S-EPMC6695444 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature