Ontology highlight
ABSTRACT:
SUBMITTER: Kou I
PROVIDER: S-EPMC6695451 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature communications 20190815 1
Adolescent idiopathic scoliosis (AIS) is the most common pediatric spinal deformity. Several AIS susceptibility loci have been identified; however, they could explain only a small proportion of AIS heritability. To identify additional AIS susceptibility loci, we conduct a meta-analysis of the three genome-wide association studies consisting of 79,211 Japanese individuals. We identify 20 loci significantly associated with AIS, including 14 previously not reported loci. These loci explain 4.6% of ...[more]