Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel.

ABSTRACT:

Background

Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis.

Objective

To quantify the frequency of germline DNA repair gene mutations in UK PCa cases and controls, in order to more comprehensively evaluate the contribution of individual genes to overall PCa risk and likelihood of aggressive disease.

Design, setting, and participants

We sequenced 167 DNA repair and eight PCa candidate genes in a UK-based cohort of 1281 young-onset PCa cases (diagnosed at ≤60yr) and 1160 selected controls.

Outcome measurements and statistical analysis

Gene-level SKAT-O and gene-set adaptive combination of p values (ADA) analyses were performed separately for cases versus controls, and aggressive (Gleason score ≥8,

SUBMITTER: Leongamornlert DA 

PROVIDER: S-EPMC6695475 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature