Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4⁺ T cells through AMPK activation.

ABSTRACT: The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4⁺T cell activation in vitro and on the inflammatory responses in T cell transfer mouse models of inflammatory bowel disease (IBD). We examined the favorable effects of BBR in vitro, using lamina propria (LP) CD4⁺ T cells in T cell transfer IBD models in which SCID mice had been injected with CD4⁺CD45RB^high T cells. BBR suppressed the frequency of IFN-γ- and Il-17A-producing LP CD4⁺ T cells. This effect was found to be regulated by AMPK activation possibly induced by oxidative phosph

SUBMITTER: Takahara M 

PROVIDER: S-EPMC6695484 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature