Association of IL-16 gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population.

ABSTRACT: Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population.Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case-control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to

SUBMITTER: Cheng F 

PROVIDER: S-EPMC6695499 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature