Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds.

ABSTRACT:

Aim

The goal of this study was to use phylogenetic evidence to determine plant families with high representation of antibacterial activity and identify potential sources to focus on for antibacterial drug discovery.

Materials & methods

We reconstructed the molecular phylogeny of plant taxa with antibacterial activity and mapped antibacterial mechanisms of action on the phylogeny.

Results

The phylogeny highlighted seven plant families (Combretaceae, Cupressaceae, Fabaceae, Lamiaceae, Lauraceae, Myrtaceae and Zingiberaceae) with disproportionately represented antibacterial activity. Phytochemicals produced were primarily involved in the disruption of the bacterial cell wall/membrane and inhibition of quorum sensing/biofilm production.

Conclusion

The study provide

SUBMITTER: Prasad MA 

PROVIDER: S-EPMC6695524 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature