Ontology highlight
ABSTRACT:
SUBMITTER: Hu T
PROVIDER: S-EPMC6695560 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Blood 20190703 7
Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming cells fated to form platelets and erythrocytes into myeloid leukemia stem cells (LSCs). <i>Prdm16s</i> expression in megakaryocyte-erythroid progenitors (MEPs), which normally lack the potential to generate granulomonocytic cells, caused AML by conve ...[more]